Intracoronary Nicorandil Relieves Multiple Coronary Vasospasm With Hemodynamic Collapse

A 49-year-old woman was referred to hospital because of chest discomfort. Coronary angiography revealed subtotal occlusion of the left coronary artery and the right coronary artery, but subsequent hemodynamic collapse occurred. Based on the results of intravascular ultrasound the occlusion was suspe...

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Bibliographic Details
Published in:Circulation Journal 2008, Vol.72(2), pp.327-330
Main Authors: Hayashi, Takaharu, Ichikawa, Minoru, Iwata, Akio, Nakata, Tsuyoshi, Lim, Young-Jae, Mishima, Masayoshi
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Coronary vasospasm
Coronary Vasospasm - diagnostic imaging
Coronary Vasospasm - drug therapy
Female
Hemodynamics - drug effects
Humans
Isosorbide Dinitrate - administration & dosage
Middle Aged
Negative remodeling
Nicorandil
Nicorandil - administration & dosage
Shock - diagnostic imaging
Shock - drug therapy
Ultrasonography
Vasodilator Agents - administration & dosage
Verapamil - administration & dosage
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Summary:A 49-year-old woman was referred to hospital because of chest discomfort. Coronary angiography revealed subtotal occlusion of the left coronary artery and the right coronary artery, but subsequent hemodynamic collapse occurred. Based on the results of intravascular ultrasound the occlusion was suspected to be caused by coronary vasospasm, which was not relieved by intracoronary injection of isosorbide dinitrate (1 mg), but was alleviated by nicorandil (2 mg), a potassium-channel opener. After discharge from hospital, the patient stopped taking her medication and returned complaining of chest discomfort again. Intravenous verapamil (5 mg) did not improve it, but direct intracoronary administration of nicorandil (2 mg) did bring relief. This case suggests that nicorandil is effective for coronary vasospasm. (Circ J 2008; 72: 327 - 330)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.72.327