Incest indices from microsatellite genotypes of mother-child pairs

BACKGROUND: Suspected incestuous paternity is encountered infrequently and investigation may be complicated by absence of the suspected father. Incest indices (IIs) can be calculated from microsatellite (STR) types of only a mother and child, but could be misleading. Therefore, the method was evalua...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2008-02, Vol.48 (2), p.341-348
Main Author: Wenk, Robert E.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Child
Female
Genotype
Humans
Incest
Male
Medical sciences
Microsatellite Repeats - genetics
Mothers
Paternity
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Victimology
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Summary:BACKGROUND: Suspected incestuous paternity is encountered infrequently and investigation may be complicated by absence of the suspected father. Incest indices (IIs) can be calculated from microsatellite (STR) types of only a mother and child, but could be misleading. Therefore, the method was evaluated. STUDY DESIGN AND METHODS: Combined incest indices (CIIs) of 50 randomly mated (RM) mothers and their children were compared with those of 50 simulated incestuous (SI) mothers and their children. Each CII was calculated from 18 individual locus IIs. Combined indices were categorized as “diagnostic” (100 for RM and SI cases, respectively), “indicative” (CII was directionally correct but not erroneously diagnostic), and “misleading” (>1.0 in RM and 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2007.01528.x