A rationally designed macrocyclic cavitand that kills bacteria with high efficacy and good selectivity

An amphiphilic macrocyclic cavitand that shows good antibacterial activity, comparable to that of peptide-based antibiotics was developed by rational design and its antibacterial selectivity over mammalian cells was examined.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2007-01 (11), p.1151-1153
Main Authors: Choi, Jinny, Kim, Jeeyeon, Kim, Kimoon, Yang, Sung-Tae, Kim, Jae-Il, Jon, Sangyong
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bridged-Ring Compounds - chemical synthesis
Bridged-Ring Compounds - chemistry
Bridged-Ring Compounds - pharmacology
Cell Survival - drug effects
Imidazoles - chemistry
Macrocyclic Compounds - chemical synthesis
Macrocyclic Compounds - chemistry
Macrocyclic Compounds - pharmacology
Mice
Microbial Sensitivity Tests
NIH 3T3 Cells
Unilamellar Liposomes - metabolism
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Description
Summary:An amphiphilic macrocyclic cavitand that shows good antibacterial activity, comparable to that of peptide-based antibiotics was developed by rational design and its antibacterial selectivity over mammalian cells was examined.
ISSN:1359-7345
1364-548X
DOI:10.1039/b617005f