Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case–control study and a pooled meta-analysis

Encouraged by recent studies on the MTHFR 677C>T polymorphism and breast cancer risk that suggested an association of the 677 TT genotype with increased breast cancer susceptibility in premenopausal women, we performed an analysis of the relationship between breast cancer risk and the MTHFR 677C&...

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Bibliographic Details
Published in:Breast cancer research and treatment 2008-02, Vol.107 (3), p.459-460
Main Authors: Langsenlehner, Tanja, Renner, Wilfried, Yazdani-Biuki, Babak, Langsenlehner, Uwe
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - genetics
Cancer research
Case-Control Studies
Female
Genotype & phenotype
Humans
Letter to the Editor
Medicine
Medicine & Public Health
Meta-Analysis as Topic
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Oncology
Pathology
Polymorphism, Genetic
Risk factors
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Summary:Encouraged by recent studies on the MTHFR 677C>T polymorphism and breast cancer risk that suggested an association of the 677 TT genotype with increased breast cancer susceptibility in premenopausal women, we performed an analysis of the relationship between breast cancer risk and the MTHFR 677C>T polymorphism in 210 premenopausal breast cancer patients and sex- and agematched healthy control subjects. Our data show a trend for a higher MTHFR 677T allele frequency in breast cancer cases (61.9%) than in controls (51.5%, P = 0.082) supporting the results of previous studies.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-007-9564-1