Treatment of Hyperglycemia In Ischemic Stroke (THIS) : A Randomized Pilot Trial

Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction. We conducted a randomized, multicenter, blinded pilot trial fo...

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Bibliographic Details
Published in:Stroke (1970) 2008-02, Vol.39 (2), p.384-389
Main Authors: BRUNO, Askiel, KENT, Thomas A, COULL, Bruce M, SHANKAR, Ravi R, SAHA, Chandan, BECKER, Kyra J, KISSELA, Brett M, WILLIAMS, Linda S
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Biological and medical sciences
Blood Glucose
Brain Ischemia - complications
Cardiovascular system
Diabetes Mellitus - drug therapy
Female
Humans
Hyperglycemia - complications
Hyperglycemia - drug therapy
Hypoglycemic Agents - administration & dosage
Insulin - administration & dosage
Male
Medical sciences
Middle Aged
Neurology
Pharmacology. Drug treatments
Pilot Projects
Recovery of Function - drug effects
Stroke - complications
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
Vasodilator agents. Cerebral vasodilators
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Summary:Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction. We conducted a randomized, multicenter, blinded pilot trial for patients with cerebral infarction within 12 hours after onset, a baseline glucose value >or=8.3 mmol/L (>or=150 mg/dL), and a National Institutes of Health Stroke Scale score of 3 to 22. Patients were randomized 2:1 to aggressive treatment with continuous intravenous insulin or subcutaneous insulin QID as needed (usual care). Target glucose levels were
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.107.493544