Prospective Study of High-Sensitivity C-Reactive Protein as a Determinant of Mortality: Results from the MONICA/KORA Augsburg Cohort Study, 1984-1998

C-reactive protein (CRP), an exquisitely sensitive systemic marker of inflammation, has emerged as an independent predictor of cardiovascular diseases (CVD). Because other chronic diseases are also associated with an inflammatory response, we sought to assess the association of high-sensitivity CRP...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2008-02, Vol.54 (2), p.335-342
Main Authors: Koenig, Wolfgang, Khuseyinova, Natalie, Baumert, Jens, Meisinger, Christa
Format: Article
Language:English
Subjects:
Adult
Aged
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cholesterol
Death, Sudden, Cardiac - epidemiology
European Continental Ancestry Group
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Germany - epidemiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical research
Medical sciences
Middle Aged
Mortality
Neoplasms - diagnosis
Neoplasms - mortality
Prospective Studies
Proteins
Regression analysis
Risk Assessment
Risk Factors
Studies
Womens health
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Summary:C-reactive protein (CRP), an exquisitely sensitive systemic marker of inflammation, has emerged as an independent predictor of cardiovascular diseases (CVD). Because other chronic diseases are also associated with an inflammatory response, we sought to assess the association of high-sensitivity CRP (hsCRP) with total and cause-specific mortality in a large cohort of middle-aged men. We measured hsCRP at baseline in 3620 middle-aged men, randomly drawn from 3 samples of the general population in the Augsburg area (Southern 0Germany) in 1984-85, 1989-90, and 1994-95. Outcome was defined as all deaths, fatal CVD, fatal coronary heart disease (CHD) including sudden cardiac deaths, and cancer deaths. During an average follow-up of 7.1 years, 408 deaths occurred (CVD 196, CHD 129, cancer 127). In multivariable Cox regression analysis, subjects with hsCRP >3 mg/L at baseline showed an almost 2-fold increased risk to die vs those with hsCRP
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2007.100271