Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors

• Published in: American journal of obstetrics and gynecology 2007-03, Vol.196 (3), p.243.e1-243.e5
• Main Authors: Huang, Gloria S., MD, Gebb, Juliana S., MD, Einstein, Mark H., MD, MS, Shahabi, Shohreh, MD, Novetsky, Akiva P., BS, Goldberg, Gary L., MD
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Curettage; endometrial biopsy; endometrial carcinoma; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Frozen Sections; Gynecology. Andrology. Obstetrics; Humans; Hysterectomy; Medical sciences; Obstetrics and Gynecology; predictive testing; Preoperative Care; Reproducibility of Results; Sensitivity and Specificity
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2006.09.035

Objective This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. Study design Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage to diagnose high-grade endometrial tumors (grade 3 endometrioid adenocarcinoma, serous carcinoma, carcinosarcoma, clear cell carcinoma) was determined. Agreement between preoperative and hysterectomy diagnoses was measured by the Kappa statistic. Results Sensitivity of Pipelle and curettage was 93.8% and 97% in patients with low-grade cancer and 99.2% and 100% in patients with high-grade cancer. Good agreement was observed between the preoperative and the hysterectomy histologic diagnoses (Kappa = 0.69), and between the preoperative and hysterectomy tumor grade (Kappa=0.78). Conclusion Preoperative endometrial sampling with Pipelle or curettage is sensitive and accurate for the diagnosis of high-grade endometrial tumors, including tumors with nonendometrioid histology.