Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA

We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2008/02/01, Vol.31(2), pp.246-249
Main Authors: Kitamura, Yoshihisa, Fujitani, Yoshika, Kitagawa, Kouhei, Miyazaki, Toshiaki, Sagara, Hidenori, Kawasaki, Hiromu, Shibata, Kazuhiko, Sendo, Toshiaki, Gomita, Yutaka
Format: Article
Language:English
Subjects:
5-HT2A receptor
adrenocorticotropic hormone
Adrenocorticotropic Hormone - pharmacology
Animals
Antidepressive Agents, Second-Generation - pharmacology
Antidepressive Agents, Tricyclic - pharmacology
bupropion
Bupropion - pharmacology
forced swim test
imipramine
Imipramine - pharmacology
Male
Motor Activity - drug effects
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT2A - biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
Swimming - psychology
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Summary:We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT2A receptor mRNA levels may be involved in this phenomenon.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.31.246