Loading…
Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA
We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic...
Saved in:
| Published in: | Biological & Pharmaceutical Bulletin 2008/02/01, Vol.31(2), pp.246-249 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413 |
| container_end_page | 249 |
| container_issue | 2 |
| container_start_page | 246 |
| container_title | Biological & Pharmaceutical Bulletin |
| container_volume | 31 |
| creator | Kitamura, Yoshihisa Fujitani, Yoshika Kitagawa, Kouhei Miyazaki, Toshiaki Sagara, Hidenori Kawasaki, Hiromu Shibata, Kazuhiko Sendo, Toshiaki Gomita, Yutaka |
| description | We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT2A receptor mRNA levels may be involved in this phenomenon. |
| doi_str_mv | 10.1248/bpb.31.246 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70246946</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70246946</sourcerecordid><originalsourceid>FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413</originalsourceid><addsrcrecordid>eNpFkc2O0zAQxyMEYrsLFx4A-cQBKcUfcT64oNJtaaUVSKWcLceesK6SOGs7C_tAvCfOpiySPdZ4fvP3jCdJ3hC8JDQrP9RDvWRkSbP8WbIgLCtSTgl_nixwRco0J7y8SC69P2GMC0zZy-SClJRVtCSL5M-maUAFj2yD9p0ZnOxMD0j2Gn0eB2cHY3sUV7gFdD06GR79ie1sbVoTHiZvtT7u0qMDGUCjg4xyZk7ZWqfi1fdfpkNH8OEj2vf3tr2HDvowZU7Q5vfgwPuzMk93R7pCB1AwBOtQd_i6epW8aGTr4fX5vEp-bDfH9S69-fZlv17dpCqnOKS14lLVqq6I5IxlTaM1q7QuuG64xlmpKaE5KIJ1yXmhioLKghQNyKrGVZURdpW8m3Vj53djrFd0xitoW9mDHb2I35flVZZH8P0MKme9d9CIwZlOugdBsJiGIuJQBCOCPsJvz6pj3YH-j56nEIHtDMSoUbK1fRuHIE52dH1sVyhf1Ma2VlCMS4ExI5gKTOKO8pOpeFRik9CnWejkg_wJTy9JF4xq4amo2UzJ_yLqVjoBPfsLSYi1Zw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70246946</pqid></control><display><type>article</type><title>Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA</title><source>Free Full-Text Journals in Chemistry</source><creator>Kitamura, Yoshihisa ; Fujitani, Yoshika ; Kitagawa, Kouhei ; Miyazaki, Toshiaki ; Sagara, Hidenori ; Kawasaki, Hiromu ; Shibata, Kazuhiko ; Sendo, Toshiaki ; Gomita, Yutaka</creator><creatorcontrib>Kitamura, Yoshihisa ; Fujitani, Yoshika ; Kitagawa, Kouhei ; Miyazaki, Toshiaki ; Sagara, Hidenori ; Kawasaki, Hiromu ; Shibata, Kazuhiko ; Sendo, Toshiaki ; Gomita, Yutaka ; aDepartment of Pharmaceutical Care and Health Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University ; cDepartment of Pharmaceutical Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University ; bDepartment of Hospital Pharmacy Okayama University Medical School</creatorcontrib><description>We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT2A receptor mRNA levels may be involved in this phenomenon.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.246</identifier><identifier>PMID: 18239281</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>5-HT2A receptor ; adrenocorticotropic hormone ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Antidepressive Agents, Second-Generation - pharmacology ; Antidepressive Agents, Tricyclic - pharmacology ; bupropion ; Bupropion - pharmacology ; forced swim test ; imipramine ; Imipramine - pharmacology ; Male ; Motor Activity - drug effects ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT2A - biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; Swimming - psychology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/02/01, Vol.31(2), pp.246-249</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413</citedby><cites>FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18239281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitamura, Yoshihisa</creatorcontrib><creatorcontrib>Fujitani, Yoshika</creatorcontrib><creatorcontrib>Kitagawa, Kouhei</creatorcontrib><creatorcontrib>Miyazaki, Toshiaki</creatorcontrib><creatorcontrib>Sagara, Hidenori</creatorcontrib><creatorcontrib>Kawasaki, Hiromu</creatorcontrib><creatorcontrib>Shibata, Kazuhiko</creatorcontrib><creatorcontrib>Sendo, Toshiaki</creatorcontrib><creatorcontrib>Gomita, Yutaka</creatorcontrib><creatorcontrib>aDepartment of Pharmaceutical Care and Health Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</creatorcontrib><creatorcontrib>cDepartment of Pharmaceutical Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</creatorcontrib><creatorcontrib>bDepartment of Hospital Pharmacy Okayama University Medical School</creatorcontrib><title>Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT2A receptor mRNA levels may be involved in this phenomenon.</description><subject>5-HT2A receptor</subject><subject>adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Antidepressive Agents, Second-Generation - pharmacology</subject><subject>Antidepressive Agents, Tricyclic - pharmacology</subject><subject>bupropion</subject><subject>Bupropion - pharmacology</subject><subject>forced swim test</subject><subject>imipramine</subject><subject>Imipramine - pharmacology</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Serotonin, 5-HT2A - biosynthesis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Swimming - psychology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkc2O0zAQxyMEYrsLFx4A-cQBKcUfcT64oNJtaaUVSKWcLceesK6SOGs7C_tAvCfOpiySPdZ4fvP3jCdJ3hC8JDQrP9RDvWRkSbP8WbIgLCtSTgl_nixwRco0J7y8SC69P2GMC0zZy-SClJRVtCSL5M-maUAFj2yD9p0ZnOxMD0j2Gn0eB2cHY3sUV7gFdD06GR79ie1sbVoTHiZvtT7u0qMDGUCjg4xyZk7ZWqfi1fdfpkNH8OEj2vf3tr2HDvowZU7Q5vfgwPuzMk93R7pCB1AwBOtQd_i6epW8aGTr4fX5vEp-bDfH9S69-fZlv17dpCqnOKS14lLVqq6I5IxlTaM1q7QuuG64xlmpKaE5KIJ1yXmhioLKghQNyKrGVZURdpW8m3Vj53djrFd0xitoW9mDHb2I35flVZZH8P0MKme9d9CIwZlOugdBsJiGIuJQBCOCPsJvz6pj3YH-j56nEIHtDMSoUbK1fRuHIE52dH1sVyhf1Ma2VlCMS4ExI5gKTOKO8pOpeFRik9CnWejkg_wJTy9JF4xq4amo2UzJ_yLqVjoBPfsLSYi1Zw</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Kitamura, Yoshihisa</creator><creator>Fujitani, Yoshika</creator><creator>Kitagawa, Kouhei</creator><creator>Miyazaki, Toshiaki</creator><creator>Sagara, Hidenori</creator><creator>Kawasaki, Hiromu</creator><creator>Shibata, Kazuhiko</creator><creator>Sendo, Toshiaki</creator><creator>Gomita, Yutaka</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA</title><author>Kitamura, Yoshihisa ; Fujitani, Yoshika ; Kitagawa, Kouhei ; Miyazaki, Toshiaki ; Sagara, Hidenori ; Kawasaki, Hiromu ; Shibata, Kazuhiko ; Sendo, Toshiaki ; Gomita, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>5-HT2A receptor</topic><topic>adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Antidepressive Agents, Second-Generation - pharmacology</topic><topic>Antidepressive Agents, Tricyclic - pharmacology</topic><topic>bupropion</topic><topic>Bupropion - pharmacology</topic><topic>forced swim test</topic><topic>imipramine</topic><topic>Imipramine - pharmacology</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Serotonin, 5-HT2A - biosynthesis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Swimming - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitamura, Yoshihisa</creatorcontrib><creatorcontrib>Fujitani, Yoshika</creatorcontrib><creatorcontrib>Kitagawa, Kouhei</creatorcontrib><creatorcontrib>Miyazaki, Toshiaki</creatorcontrib><creatorcontrib>Sagara, Hidenori</creatorcontrib><creatorcontrib>Kawasaki, Hiromu</creatorcontrib><creatorcontrib>Shibata, Kazuhiko</creatorcontrib><creatorcontrib>Sendo, Toshiaki</creatorcontrib><creatorcontrib>Gomita, Yutaka</creatorcontrib><creatorcontrib>aDepartment of Pharmaceutical Care and Health Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</creatorcontrib><creatorcontrib>cDepartment of Pharmaceutical Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</creatorcontrib><creatorcontrib>bDepartment of Hospital Pharmacy Okayama University Medical School</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitamura, Yoshihisa</au><au>Fujitani, Yoshika</au><au>Kitagawa, Kouhei</au><au>Miyazaki, Toshiaki</au><au>Sagara, Hidenori</au><au>Kawasaki, Hiromu</au><au>Shibata, Kazuhiko</au><au>Sendo, Toshiaki</au><au>Gomita, Yutaka</au><aucorp>aDepartment of Pharmaceutical Care and Health Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</aucorp><aucorp>cDepartment of Pharmaceutical Sciences Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University</aucorp><aucorp>bDepartment of Hospital Pharmacy Okayama University Medical School</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>31</volume><issue>2</issue><spage>246</spage><epage>249</epage><pages>246-249</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)2A receptor function in the form of 5-HT2A receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT2A receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT2A receptor mRNA levels may be involved in this phenomenon.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18239281</pmid><doi>10.1248/bpb.31.246</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2008/02/01, Vol.31(2), pp.246-249 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70246946 |
| source | Free Full-Text Journals in Chemistry |
| subjects | 5-HT2A receptor adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Animals Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Tricyclic - pharmacology bupropion Bupropion - pharmacology forced swim test imipramine Imipramine - pharmacology Male Motor Activity - drug effects Rats Rats, Wistar Receptor, Serotonin, 5-HT2A - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Swimming - psychology |
| title | Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test: Involvement of the Expression of 5-HT2A Receptor mRNA |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T04%3A19%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Imipramine%20and%20Bupropion%20on%20the%20Duration%20of%20Immobility%20of%20ACTH-Treated%20Rats%20in%20the%20Forced%20Swim%20Test:%20Involvement%20of%20the%20Expression%20of%205-HT2A%20Receptor%20mRNA&rft.jtitle=Biological%20&%20Pharmaceutical%20Bulletin&rft.au=Kitamura,%20Yoshihisa&rft.aucorp=aDepartment%20of%20Pharmaceutical%20Care%20and%20Health%20Sciences%20Graduate%20School%20of%20Medicine%20Dentistry%20and%20Pharmaceutical%20Sciences%20Okayama%20University&rft.date=2008-02-01&rft.volume=31&rft.issue=2&rft.spage=246&rft.epage=249&rft.pages=246-249&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.31.246&rft_dat=%3Cproquest_cross%3E70246946%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c620t-bc5acbcb91a5334ffdd39dd75df5d048d2126ec10d8557c772a717fea9b099413%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70246946&rft_id=info:pmid/18239281&rfr_iscdi=true |