Meta-analysis of first trimester Down syndrome screening studies: free β-human chorionic gonadotropin significantly outperforms intact human chorionic gonadotropin in a multimarker protocol

Objective The purpose of this study was to compare free β and intact human chorionic gonadotropin in first trimester screening with pregnancy-associated plasma protein-A and nuchal translucency. Study Design A Monte Carlo simulation trial was conducted based on a literature review of the PUBMED data...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2007-03, Vol.196 (3), p.198-205
Main Authors: Evans, Mark I., MD, Krantz, David A., MA, Hallahan, Terrence W., PhD, Galen, Robert S., MD, MPH
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Chorionic Gonadotropin - blood
Chorionic Gonadotropin, beta Subunit, Human - blood
Chromosome aberrations
Clinical Protocols
Down Syndrome - diagnosis
Down syndrome screening
Female
first trimester
free β-human chorionic gonadotropin
Gynecology. Andrology. Obstetrics
Humans
intact human chorionic gonadotropin
Medical genetics
Medical sciences
Obstetrics and Gynecology
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A - analysis
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Summary:Objective The purpose of this study was to compare free β and intact human chorionic gonadotropin in first trimester screening with pregnancy-associated plasma protein-A and nuchal translucency. Study Design A Monte Carlo simulation trial was conducted based on a literature review of the PUBMED database (1966 to November 2005). Results In younger patients (
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2006.08.001