Notch, Myc and Breast Cancer

The involvement of Myc in the development of human breast cancer is known for quite some time, but an analogous role of Notch signaling is only now emerging from fragmented pieces of information. Recently, a Notch/Myc relationship in oncogenesis was revealed from a mouse model, in which mammary tumo...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2007-02, Vol.6 (4), p.418-429
Main Authors: Efstratiadis, Argiris, Szabolcs, Matthias, Klinakis, Apostolos
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified - metabolism
Binding
Biology
Bioscience
Breast - metabolism
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Calcium
Cancer
Carcinoma - genetics
Carcinoma - metabolism
Cell
Cycle
Evolution, Molecular
Humans
Landes
Leukemia-Lymphoma, Adult T-Cell - genetics
Mammary Glands, Animal - metabolism
Mammary Neoplasms, Experimental - genetics
Mammary Neoplasms, Experimental - metabolism
Mice
Organogenesis
Phylogeny
Proteins
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Proto-Oncogene Proteins c-myc - physiology
Receptor, Notch1 - genetics
Receptor, Notch1 - metabolism
Receptor, Notch1 - physiology
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Summary:The involvement of Myc in the development of human breast cancer is known for quite some time, but an analogous role of Notch signaling is only now emerging from fragmented pieces of information. Recently, a Notch/Myc relationship in oncogenesis was revealed from a mouse model, in which mammary tumors are induced by the intracellular domain of Notch1 (N1IC). In fact, a combination of genetic and molecular data demonstrated that Myc is a direct transcriptional target of Notch1 participating as an indispensable downstream effector in N1IC-induced tumorigenic action. A medically-relevant correlative observation based on immunophenotyping was the co-expression of Notch1 and Myc in a significant fraction of human breast cancer specimens. A Notch1/Myc oncogenic association was also observed in T-cell acute lymphoblastic leukemia.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.6.4.3838