Association of Impaired Thrombolysis In Myocardial Infarction Myocardial Perfusion Grade With Ventricular Tachycardia and Ventricular Fibrillation Following Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction

• Published in: Journal of the American College of Cardiology 2008-02, Vol.51 (5), p.546-551
• Main Authors: Gibson, C. Michael, MS, MD, FACC, Pride, Yuri B., MD, Buros, Jacqueline L., BA, Lord, Erin, BA, Shui, Amy, MA, Murphy, Sabina A., MPH, Pinto, Duane S., MD, FACC, Zimetbaum, Peter J., MD, FACC, Sabatine, Marc S., MD, MPH, FACC, Cannon, Christopher P., MD, FACC, Josephson, Mark E., MD, FACC
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty, Balloon, Coronary; Aspirin - therapeutic use; Biological and medical sciences; Cardiac dysrhythmias; Cardiology; Cardiology. Vascular system; Cardiovascular; Coronary Angiography; Coronary Circulation; Coronary heart disease; Double-Blind Method; Drug therapy; Drug Therapy, Combination; Electrocardiography; Female; Heart; Heart attacks; Humans; Incidence; Internal Medicine; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Mortality; Myocardial Infarction - complications; Myocardial Infarction - drug therapy; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocarditis. Cardiomyopathies; Platelet Aggregation Inhibitors - therapeutic use; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tachycardia, Ventricular - epidemiology; Tachycardia, Ventricular - etiology; Thrombolytic Therapy; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Treatment Outcome; Ventricular Fibrillation - epidemiology; Ventricular Fibrillation - etiology
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.08.061

Association of Impaired Thrombolysis In Myocardial Infarction Myocardial Perfusion Grade With Ventricular Tachycardia and Ventricular Fibrillation Following Fibrinolytic Therapy for ST-Segment Elevation Myocardial Infarction C. Michael Gibson, Yuri B. Pride, Jacqueline L. Buros, Erin Lord, Amy Shui, Sabina A. Murphy, Duane S. Pinto, Peter J. Zimetbaum, Marc S. Sabatine, Christopher P. Cannon, Mark E. Josephson, for the TIMI Study Group In the CLARITY-TIMI 28 (Clopidogrel as Adjunctive Reperfusion Therapy–Thrombolysis In Myocardial Infarction 28) study, patients treated with fibrinolytic therapy for ST-segment elevation myocardial infarction were scheduled for late angiography. Impaired myocardial perfusion, as assessed by the Thrombolysis In Myocardial Infarction (TIMI) myocardial perfusion grade, was associated with an increased incidence of ventricular tachycardia or ventricular fibrillation. This relationship held true even among patients with restoration of normal flow (TIMI flow grade 3) and those with preserved or moderately reduced left ventricular systolic function (left ventricular ejection fraction ≥30%) and was noted both before and after angiography.