Osteoprotegerin levels in peri-implant crevicular fluid

• Published in: Clinical oral implants research 2008-03, Vol.19 (3), p.283-288
• Main Authors: Arıkan, Fatih, Buduneli, Nurcan, Kütükçüler, Necil
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alveolar Bone Loss - metabolism; Biomarkers; Dental Implantation, Endosseous; Dental Implants; Dentistry; ELISA; endosseous dental implants; Enzyme-Linked Immunosorbent Assay; Female; Gingival Crevicular Fluid - chemistry; Humans; Male; Middle Aged; osteoprotegerin; Osteoprotegerin - analysis; Osteoprotegerin - metabolism; peri-implant crevicular fluid; Periodontal Index; Periodontitis - metabolism; RANK Ligand - analysis; RANK Ligand - metabolism; sRANKL; Statistics, Nonparametric
• ISSN: 0905-7161; 1600-0501
• DOI: 10.1111/j.1600-0501.2007.01463.x

Aims: To evaluate the levels of soluble receptor activator of nuclear factor‐κB ligand (sRANKL) and osteoprotegerin (OPG) in crevicular fluid of endosseous dental implants. Methods: Eighty‐six implants in 39 patients were evaluated. All patients were treated with root‐type implants placed at least 16 months and loaded at least 12 months before the examination. Peri‐implant crevicular fluid (PICF) samples were obtained from buccal and lingual aspects of implants. Modified plaque index, probing depth, gingival index, and bleeding on probing (BOP) were recorded at four sites per implant. PICF levels of sRANKL and OPG were analysed by ELISA. Spearman's correlations were utilised to relate biochemical data and clinical parameters. Results: The PICF level of sRANKL did not show significant correlation with the clinical parameters or the OPG level. The total amount of OPG was positively correlated with PICF volume, gingival index, and BOP (P