Low Molecular Weight Heparin Treatment Decreases MMP-9 Plasma Activity in Patients with Abdominal Aortic Aneurysm

Large abdominal aortic aneurysms (AAAs) are associated with coagulation abnormalities, which are significantly reduced by low molecular weight heparin (LMWH). Considering anti-inflammatory properties of heparin we verified, whether LMWH influences MMP-2/-9 in AAA patients. The study involved 26 AAA...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2008-02, Vol.35 (2), p.159-161
Main Authors: Grzela, T, Brawura-Biskupski-Samaha, R, Jelenska, M.M, Szmidt, J
Format: Article
Language:English
Subjects:
AAA, abdominal aortic aneurysm
Aged
Anticoagulants - therapeutic use
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - drug therapy
Aortic Aneurysm, Abdominal - enzymology
Aortic Aneurysm, Abdominal - surgery
Blood Coagulation - drug effects
Combined Modality Therapy
Down-Regulation
Female
Heparin, Low-Molecular-Weight - therapeutic use
Humans
LMWH, low molecular weight heparin
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Middle Aged
MMP-9, matrix metalloproteinase
Surgery
Time Factors
Treatment Outcome
Vascular Surgical Procedures
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Summary:Large abdominal aortic aneurysms (AAAs) are associated with coagulation abnormalities, which are significantly reduced by low molecular weight heparin (LMWH). Considering anti-inflammatory properties of heparin we verified, whether LMWH influences MMP-2/-9 in AAA patients. The study involved 26 AAA individuals, 10 patients with coagulation abnormalities received LMWH and 16 were a control group. The plasma activity of MMP-2/-9 was measured using zymography. We found that, in addition to the reduction of coagulation abnormalities, LMWH treatment was associated with the decreased MMP-9 but not MMP-2 activity. Therefore, LMWH use could be considered as a valuable pretreatment before an elective aneurysm repair.
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2007.09.008