Cultivation of Plasmodium vivax

Establishment of a continuous line of Plasmodium vivax parasite is crucial to understand the parasite's biology; however, this has not yet been achieved. Beginning in the 19th century, there were several efforts to cultivate this malaria parasite but without much success until the late 1980s. I...

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Bibliographic Details
Published in:Trends in parasitology 2008-02, Vol.24 (2), p.85-88
Main Authors: Udomsangpetch, Rachanee, Kaneko, Osamu, Chotivanich, Kesinee, Sattabongkot, Jetsumon
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line
Culture Media
Culture Techniques
Erythroblasts - parasitology
Erythrocytes - parasitology
Gastroenterology and Hepatology
Human protozoal diseases
Humans
Infectious Disease
Infectious diseases
Malaria
Medical sciences
Parasitic diseases
Parasitology - methods
Plasmodium vivax
Plasmodium vivax - growth & development
Protozoal diseases
Reticulocytes - parasitology
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Summary:Establishment of a continuous line of Plasmodium vivax parasite is crucial to understand the parasite's biology; however, this has not yet been achieved. Beginning in the 19th century, there were several efforts to cultivate this malaria parasite but without much success until the late 1980s. In addition, to date, only minor modifications of the methodology have been investigated, which has resulted in extending the cultivation period to around four weeks by supplying reticulocytes obtained from normal blood or rare hemochromatotic blood. However, the use of laboratory-produced erythroblasts to cultivate P. vivax enables maintenance of a continuous line of the parasite stably in the laboratory. Here, we summarize and compare the available methodologies and conditions for the in vitro cultivation of P. vivax.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2007.09.010