Further Evidence for BRCA1 Communication with the Inactive X Chromosome

BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inact...

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Bibliographic Details
Published in:Cell 2007-03, Vol.128 (5), p.991-1002
Main Authors: Silver, Daniel P., Dimitrov, Stoil D., Feunteun, Jean, Gelman, Rebecca, Drapkin, Ronny, Lu, Shihua D., Shestakova, Elena, Velmurugan, Soundarapandian, DeNunzio, Nicholas, Dragomir, Serban, Mar, Jessica, Liu, Xiaoling, Rottenberg, Sven, Jonkers, Jos, Ganesan, Shridar, Livingston, David M.
Format: Article
Language:English
Subjects:
Animals
BRCA1 Protein - genetics
BRCA1 Protein - metabolism
Cell Line, Tumor
Embryo, Mammalian - cytology
Female
Fibroblasts
Genes, BRCA1
Genes, BRCA2
Mammary Neoplasms, Experimental - genetics
Mammary Neoplasms, Experimental - metabolism
Mice
Mutation
RNA Interference
RNA, Long Noncoding
RNA, Untranslated - metabolism
X Chromosome - metabolism
X Chromosome Inactivation
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Summary:BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells ( Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2007.02.025