Evaluation of neuroendocrine status in longevity

Abstract It is well known that physiological changes in the neuroendocrine system may be related to the process of aging. To assess neuroendocrine status in aging humans we studied a group of 155 women including 78 extremely old women (centenarians) aged 100–115 years, 21 early elderly women aged 64...

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Bibliographic Details
Published in:Neurobiology of aging 2007-05, Vol.28 (5), p.774-783
Main Authors: Baranowska, Boguslawa, Wolinska-Witort, Ewa, Bik, Wojciech, Baranowska-Bik, Agnieszka, Martynska, Lidia, Chmielowska, Magdalena
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - blood
Centenarians
Female
Hormones
Humans
Internal Medicine
Leptin
Longevity - physiology
Middle Aged
Neurology
Neuropeptides - blood
Neurosecretory Systems - metabolism
NPY
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Summary:Abstract It is well known that physiological changes in the neuroendocrine system may be related to the process of aging. To assess neuroendocrine status in aging humans we studied a group of 155 women including 78 extremely old women (centenarians) aged 100–115 years, 21 early elderly women aged 64–67 years, 21 postmenopausal women aged 50–60 years and 35 younger women aged 20–50 years. Plasma NPY, leptin, glucose, insulin and lipid profiles were evaluated, and serum concentrations of pituitary, adrenal and thyroid hormones were measured. Our data revealed several differences in the neuroendocrine and metabolic status of centenarians, compared with other age groups, including the lowest serum concentrations of leptin, insulin and T3, and the highest values for prolactin. We failed to find any significant differences in TSH and cortisol levels. On the other hand, LH and FSH levels were comparable with those in the elderly and postmenopausal groups, but they were significantly higher than in younger subjects. GH concentrations in centenarians were lower than in younger women. NPY values were highest in the elderly group and lowest in young subjects. We conclude that the neuroendocrine status in centenarians is markedly different from that found in early elderly or young women.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2006.03.014