Fas/Fas-ligand Expressions in Primary Breast Cancer are Significant Predictors of its Skeletal Spread

Background: Bones belong to the most frequent localizations of breast cancer metastases. Several studies on female breast malignancies have indicated that Fas/Fas-ligand status may have a significant impact on survival. Hence, the aim of our study was to determine if these molecules might serve as t...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2007-01, Vol.27 (1A), p.215-218
Main Authors: BEBENEK, Marek, DUS, Danuta, KOZLAK, Joanna
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Bone Neoplasms - secondary
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Fas Ligand Protein - biosynthesis
fas Receptor - biosynthesis
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Predictive Value of Tests
Risk Factors
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Bones belong to the most frequent localizations of breast cancer metastases. Several studies on female breast malignancies have indicated that Fas/Fas-ligand status may have a significant impact on survival. Hence, the aim of our study was to determine if these molecules might serve as the predictors of skeletal dissemination in radically-treated breast cancer patients. Patients and Methods: Tumor samples from 147 radically-treated breast cancer patients were studied immunohistochemically for Fas/Fas-ligand expression. Results: Both Fas and Fas-ligand expression in the primary tumor were considerably less frequent among breast cancer patients with bone metastases compared to women without skeletal spread. Moreover, negative staining for Fas or the lack of Fas-ligand expression proved to be significant predictors for the survival free from bone metastases under univariate analysis. Conclusion: Our results suggest that the probability of bone metastases may be assessed on the basis of Fas/Fas-ligand expression in primary breast cancer. Consequently, their determination seems crucial for further prognosis and determination of adjuvant treatment.
ISSN:0250-7005
1791-7530