Rapid switch from oral antiparkinsonian combination drug therapy to duodenal levodopa infusion

Six patients with Parkinson's disease (PD) with severe motor complications were directly switched from their oral antiparkinsonian combination drug regime to nasoduodenal levodopa infusion without previously recommended transient treatment with levodopa alone. Duodenal levodopa infusion reduced...

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Bibliographic Details
Published in:Movement disorders 2008-01, Vol.23 (1), p.145-146
Main Authors: Meiler, Birgit, Andrich, Jürgen, Müller, Thomas
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Drug Therapy, Combination
Duodenum
Female
Humans
Infusions, Parenteral
Jejunostomy
Levodopa - administration & dosage
Levodopa - therapeutic use
levodopa infusion
Male
Medical sciences
Neurology
Neuropharmacology
Parkinson Disease - drug therapy
Parkinson's disease
Pharmacology. Drug treatments
Time Factors
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Description
Summary:Six patients with Parkinson's disease (PD) with severe motor complications were directly switched from their oral antiparkinsonian combination drug regime to nasoduodenal levodopa infusion without previously recommended transient treatment with levodopa alone. Duodenal levodopa infusion reduced motor complications to a considerable extent. We have shown that a prior change to an oral levodopa monotherapy and a slow titration of duodenal levodopa infusion may be skipped and a direct switch to duodenal levodopa is a safe option. © 2007 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21800