Fetal aortic stenosis and changes in amniotic fluid natriuretic peptides

Objective Natriuretic peptides, especially brain natriuretic peptide (BNP), have demonstrated great usefulness in pediatric and adult cardiology. We studied their usefulness, based on amniotic fluid concentrations, in an ovine model of fetal aortic stenosis and in response to fetal cardiac intervent...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2007-03, Vol.196 (3), p.253.e1-253.e6
Main Authors: Lubbers, Walter C., BS, Eghtesady, Pirooz, MD, PhD
Format: Article
Language:English
Subjects:
Amniotic Fluid - chemistry
Animals
Aortic Valve Stenosis - diagnosis
Biological and medical sciences
Cardiology. Vascular system
congenital
Endocardial and cardiac valvular diseases
Fetal Diseases - diagnosis
fetal intervention
Gynecology. Andrology. Obstetrics
Heart
Medical sciences
natriuretic peptide
Natriuretic Peptides - analysis
Obstetrics and Gynecology
ovine
Sheep
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Summary:Objective Natriuretic peptides, especially brain natriuretic peptide (BNP), have demonstrated great usefulness in pediatric and adult cardiology. We studied their usefulness, based on amniotic fluid concentrations, in an ovine model of fetal aortic stenosis and in response to fetal cardiac intervention. Study Design After their natural history was established with gestation (n = 18 fetuses), natriuretic peptide levels were measured in a fetal model of aortic stenosis (50-60 days; term, 148 days; n = 9) and were correlated to the severity of fetal heart disease. Response to fetal cardiac intervention in 3 hydropic fetuses was also assessed. Significance was established with 2-sided paired t -tests at a probability value of
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.01.003