Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the ext...

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Bibliographic Details
Published in:Clinical cancer research 2008-02, Vol.14 (3), p.627-632
Main Authors: PARSONS, J. Thomas, SLACK-DAVIS, Jill, TILGHMAN, Robert, GREGORY ROBERTS, W
Format: Article
Language:English
Subjects:
Adhesion Signaling Pathways
Antineoplastic agents
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Disease Progression
Focal Adhesion Kinase
Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors
Focal Adhesion Protein-Tyrosine Kinases - genetics
Focal Adhesion Protein-Tyrosine Kinases - physiology
Humans
Integrins - physiology
Medical sciences
Neoplasm Metastasis
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - pathology
Neoplasms - physiopathology
Oligonucleotides, Antisense - therapeutic use
Pharmacology. Drug treatments
Protein Kinase Inhibitors - therapeutic use
RNA, Small Interfering - genetics
Signal Transduction
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Summary:The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-07-2220