A Patient With Leg Weakness

The present case was typical in many respects for neuroinvasive WNV infection. The differential diagnosis considered was appropriately comprehensive. The present case also reminds us that little or no abnormalities will be seen on imaging in many cases, and that initial serology may be negative and...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2007-02, Vol.34 (1), p.92-98
Main Authors: Keith, Julia, Nicolle, Michael, Tugaleva, Elena, Shkrum, Michael, Bilbao, Juan, Hammond, Robert
Format: Article
Language:English
Subjects:
Aged
Antibodies, Viral - analysis
Antibodies, Viral - blood
Antibodies, Viral - immunology
Antigens, Viral - immunology
Biological and medical sciences
Brain - pathology
Brain - virology
Diagnosis, Differential
Disease Progression
Fatal Outcome
Female
Fever - etiology
Humans
Immunocompromised Host - immunology
Injuries of the nervous system and the skull. Diseases due to physical agents
Leg - physiopathology
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Muscle Weakness - physiopathology
Muscle Weakness - virology
Nervous System - immunology
Nervous System - physiopathology
Nervous System - virology
Neurology
Neurons - pathology
Neurons - virology
Paraparesis - physiopathology
Paraparesis - virology
Serologic Tests - standards
Traumas. Diseases due to physical agents
West Nile Fever - blood
West Nile Fever - diagnosis
West Nile Fever - immunology
Citations: Items that this one cites
Online Access:Get full text
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Description
Summary:The present case was typical in many respects for neuroinvasive WNV infection. The differential diagnosis considered was appropriately comprehensive. The present case also reminds us that little or no abnormalities will be seen on imaging in many cases, and that initial serology may be negative and should be repeated beyond the acute phase ante- or postmortem. Fortunately, specific antibodies are also now available for identification of viral proteins in tissue although sensitivity of the latter may be affected by the stage of infection and sampling of areas bearing a higher viral load. West Nile Virus, along with other emerging infections, serves notice of the health care implications of humanity's globalization of ecosystems.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100005862