Expression of High Mobility Group Box Chromosomal Protein-1 (HMGB-1) in Gastric Cancer

• Published in: Anticancer research 2007-01, Vol.27 (1A), p.449-457
• Main Authors: AKAIKE, Hidenori, KONO, Koji, SUGAI, Hidemitsu, TAKAHASHI, Akihiro, MIMURA, Kousaku, KAWAGUCHI, Yoshihiko, FUJII, Hideki
• Format: Article
• Language: English
• Subjects: Antigens, CD - biosynthesis; Antigens, CD - immunology; Antigens, Differentiation, Myelomonocytic - biosynthesis; Antigens, Differentiation, Myelomonocytic - immunology; Biological and medical sciences; Female; Gastroenterology. Liver. Pancreas. Abdomen; HMGB1 Protein - biosynthesis; HMGB1 Protein - immunology; Humans; Inflammation - immunology; Inflammation - pathology; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neoplasm Staging; Stomach Neoplasms - immunology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Rate; Tumors
• ISSN: 0250-7005; 1791-7530

The intranuclear architectural protein termed high mobility group box chromosomal protein 1 (HMGB-1) has recently been identified as a potent proinflammatory mediator. The release of HMGB-1 results in the activation of macrophages and leads to an inflammatory response. In the tumor microenvironment, it is well known that there are local inflammatory reactions and the degree of inflammatory cell infiltration inside a tumor is correlated to the prognosis of the disease. In the present study, the expression of HMGB-1 in gastric cancer cells was evaluated in relation to the clinicopathological findings (n=76), and its expression was analyzed in comparison to immune reactive cells in gastric cancer. The expression of HMGB-1 in gastric cancer cells with the intestinal type (90.7 positive cells per 200 cancer cells ±37.9, n=40) was significantly increased compared to that in the diffuse type (56.8±32.7, n=36) (p