Formulated antidiabetic preparation Syndrex® has a strong antioxidant activity

Syndrex® is a formulated herbal antidiabetic preparation containing powder of germinated fenugreek seeds. We have assessed the antioxidant potential of this drug. Syndrex® was fractionated by Soxhlet apparatus and fractions were used to determine their antioxidant potential at different levels. In v...

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Bibliographic Details
Published in:European journal of pharmacology 2008-02, Vol.581 (1), p.216-225
Main Authors: Dixit, Priyanjali P., Devasagayam, Thomas P.A., Ghaskadbi, Saroj
Format: Article
Language:English
Subjects:
Animals
Antidiabetic preparation
Antioxidant activity
Antioxidants - pharmacology
Biological and medical sciences
Catalase - metabolism
Female
Glutathione Reductase - metabolism
Hypoglycemic Agents - pharmacology
Insulin - metabolism
Insulin Secretion
Islets
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Lipid Peroxidation - drug effects
Male
Medical sciences
Mice
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Protein carbonyls
Rats
Rats, Wistar
Streptozocin - pharmacology
Syndrex
Thiobarbituric acid reactive substances
Trigonella
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Summary:Syndrex® is a formulated herbal antidiabetic preparation containing powder of germinated fenugreek seeds. We have assessed the antioxidant potential of this drug. Syndrex® was fractionated by Soxhlet apparatus and fractions were used to determine their antioxidant potential at different levels. In vitro activity was assessed by ferric reducing antioxidant power assay, radical scavenging by 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferrylmyoglobin/2,2'-azobis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) and pulse radiolysis. Inhibition of lipid peroxidation by Syndrex® in mitochondrial preparations from rat liver was checked. Methanolic fraction of Syndrex® exhibited the highest antioxidant activity as compared to other fractions. This fraction showed maximum phenolic and flavonoid contents. Isolated mouse pancreatic islets also employed to assess antioxidant activity of Syndrex®. Islets were treated with streptozotocin, a diabetogen known to damage islet cells by inducing generation of free radicals. Syndrex® treated islets were protected from streptozotocin insult as these islets survived better and remained functional as compared to streptozotocin treated islets.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2007.11.052