Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F...

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Bibliographic Details
Published in:Journal of microencapsulation 2008-03, Vol.25 (2), p.106-110
Main Authors: Park, Hwa Young, Oh, Keun Sang, Koo, Hyoung Mo, Cho, Sun Hang, Chung, Sang Jun, Lim, Yong Taik, Kim, Dongmin, Yuk, Soon Hong
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calorimetry, Differential Scanning
Chromatography, High Pressure Liquid
Cyclohexanols - administration & dosage
Cyclohexanols - chemistry
Delayed-Action Preparations
General pharmacology
heparin
Heparin - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate
Medical sciences
Microparticle
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
pluronic
Poloxamer - chemistry
Polyvinyl Alcohol - chemistry
polyvinylalcohol
sustained release of ionic drug
Venlafaxine Hydrochloride
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Summary:Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040701800917