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Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug
Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F...
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| Published in: | Journal of microencapsulation 2008-03, Vol.25 (2), p.106-110 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c465t-434ec4ccc8ec82b1aa3ce9587ee324365a677a72541f5b4eb88753dcd06136893 |
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| cites | cdi_FETCH-LOGICAL-c465t-434ec4ccc8ec82b1aa3ce9587ee324365a677a72541f5b4eb88753dcd06136893 |
| container_end_page | 110 |
| container_issue | 2 |
| container_start_page | 106 |
| container_title | Journal of microencapsulation |
| container_volume | 25 |
| creator | Park, Hwa Young Oh, Keun Sang Koo, Hyoung Mo Cho, Sun Hang Chung, Sang Jun Lim, Yong Taik Kim, Dongmin Yuk, Soon Hong |
| description | Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC). |
| doi_str_mv | 10.1080/02652040701800917 |
| format | article |
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Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).</description><identifier>ISSN: 0265-2048</identifier><identifier>EISSN: 1464-5246</identifier><identifier>DOI: 10.1080/02652040701800917</identifier><identifier>PMID: 18246488</identifier><identifier>CODEN: JOMIEF</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Calorimetry, Differential Scanning ; Chromatography, High Pressure Liquid ; Cyclohexanols - administration & dosage ; Cyclohexanols - chemistry ; Delayed-Action Preparations ; General pharmacology ; heparin ; Heparin - chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Medical sciences ; Microparticle ; Microspheres ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; pluronic ; Poloxamer - chemistry ; Polyvinyl Alcohol - chemistry ; polyvinylalcohol ; sustained release of ionic drug ; Venlafaxine Hydrochloride</subject><ispartof>Journal of microencapsulation, 2008-03, Vol.25 (2), p.106-110</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-434ec4ccc8ec82b1aa3ce9587ee324365a677a72541f5b4eb88753dcd06136893</citedby><cites>FETCH-LOGICAL-c465t-434ec4ccc8ec82b1aa3ce9587ee324365a677a72541f5b4eb88753dcd06136893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20144602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18246488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hwa Young</creatorcontrib><creatorcontrib>Oh, Keun Sang</creatorcontrib><creatorcontrib>Koo, Hyoung Mo</creatorcontrib><creatorcontrib>Cho, Sun Hang</creatorcontrib><creatorcontrib>Chung, Sang Jun</creatorcontrib><creatorcontrib>Lim, Yong Taik</creatorcontrib><creatorcontrib>Kim, Dongmin</creatorcontrib><creatorcontrib>Yuk, Soon Hong</creatorcontrib><title>Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug</title><title>Journal of microencapsulation</title><addtitle>J Microencapsul</addtitle><description>Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).</description><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyclohexanols - administration & dosage</subject><subject>Cyclohexanols - chemistry</subject><subject>Delayed-Action Preparations</subject><subject>General pharmacology</subject><subject>heparin</subject><subject>Heparin - chemistry</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate</subject><subject>Medical sciences</subject><subject>Microparticle</subject><subject>Microspheres</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>pluronic</subject><subject>Poloxamer - chemistry</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>polyvinylalcohol</subject><subject>sustained release of ionic drug</subject><subject>Venlafaxine Hydrochloride</subject><issn>0265-2048</issn><issn>1464-5246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxS0EokvhA3BBucAtdPzfEVyqqlCkSnAArpHjTFhXThzspGj59PVqFxBCKqc5zO89zbxHyHMKrykYOAOmJAMBGqgBaKh-QDZUKFFLJtRDstnv6wKYE_Ik5xsAkI1hj8kJNQUQxmxId4WzTX6q_TjGzgf_E_tqDmuKk3dnn76eVy6Oc8x-wWr0LsVCL94FzNUQU7VsscprXqyfiq7H4G8x7ao4VH5vUPVp_faUPBpsyPjsOE_Jl3eXny-u6uuP7z9cnF_XTii51IILdMI5Z9AZ1lFrucNGGo3ImeBKWqW11UwKOshOYGeMlrx3PSjKlWn4KXl18J1T_L5iXtrRZ4ch2Anjmltd4uDQqP-CDEDpRvIC0gNY_s454dDOyY827VoK7b6B9p8GiubF0XztRuz_KI6RF-DlEbDZ2TAkOzmff3MMqBAKWOHeHjg_laRH-yOm0LeL3YWYfon4fXe8-Uu-RRuWrbMJ25u4pqk0cc8Xd6tfs40</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Park, Hwa Young</creator><creator>Oh, Keun Sang</creator><creator>Koo, Hyoung Mo</creator><creator>Cho, Sun Hang</creator><creator>Chung, Sang Jun</creator><creator>Lim, Yong Taik</creator><creator>Kim, Dongmin</creator><creator>Yuk, Soon Hong</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug</title><author>Park, Hwa Young ; Oh, Keun Sang ; Koo, Hyoung Mo ; Cho, Sun Hang ; Chung, Sang Jun ; Lim, Yong Taik ; Kim, Dongmin ; Yuk, Soon Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-434ec4ccc8ec82b1aa3ce9587ee324365a677a72541f5b4eb88753dcd06136893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyclohexanols - administration & dosage</topic><topic>Cyclohexanols - chemistry</topic><topic>Delayed-Action Preparations</topic><topic>General pharmacology</topic><topic>heparin</topic><topic>Heparin - chemistry</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate</topic><topic>Medical sciences</topic><topic>Microparticle</topic><topic>Microspheres</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>pluronic</topic><topic>Poloxamer - chemistry</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>polyvinylalcohol</topic><topic>sustained release of ionic drug</topic><topic>Venlafaxine Hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hwa Young</creatorcontrib><creatorcontrib>Oh, Keun Sang</creatorcontrib><creatorcontrib>Koo, Hyoung Mo</creatorcontrib><creatorcontrib>Cho, Sun Hang</creatorcontrib><creatorcontrib>Chung, Sang Jun</creatorcontrib><creatorcontrib>Lim, Yong Taik</creatorcontrib><creatorcontrib>Kim, Dongmin</creatorcontrib><creatorcontrib>Yuk, Soon Hong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of microencapsulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hwa Young</au><au>Oh, Keun Sang</au><au>Koo, Hyoung Mo</au><au>Cho, Sun Hang</au><au>Chung, Sang Jun</au><au>Lim, Yong Taik</au><au>Kim, Dongmin</au><au>Yuk, Soon Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug</atitle><jtitle>Journal of microencapsulation</jtitle><addtitle>J Microencapsul</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>25</volume><issue>2</issue><spage>106</spage><epage>110</epage><pages>106-110</pages><issn>0265-2048</issn><eissn>1464-5246</eissn><coden>JOMIEF</coden><abstract>Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>18246488</pmid><doi>10.1080/02652040701800917</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-2048 |
| ispartof | Journal of microencapsulation, 2008-03, Vol.25 (2), p.106-110 |
| issn | 0265-2048 1464-5246 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70263096 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Biological and medical sciences Calorimetry, Differential Scanning Chromatography, High Pressure Liquid Cyclohexanols - administration & dosage Cyclohexanols - chemistry Delayed-Action Preparations General pharmacology heparin Heparin - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate Medical sciences Microparticle Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments pluronic Poloxamer - chemistry Polyvinyl Alcohol - chemistry polyvinylalcohol sustained release of ionic drug Venlafaxine Hydrochloride |
| title | Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug |
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