Integrin signaling is integral to regeneration

The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute to regeneration failure. In this review, we focus on intrinsic factors that impact regeneration, in particular integrin rec...

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Bibliographic Details
Published in:Experimental neurology 2008-02, Vol.209 (2), p.343-352
Main Authors: Lemons, Michele L., Condic, Maureen L.
Format: Article
Language:English
Subjects:
Animals
Chondroitin sulfate proteoglycans
CSPGs
FAK
Gene Expression Regulation - physiology
Growth cone
Guidance
Humans
Integrin receptors
Integrins - physiology
Models, Biological
Motility
Nerve Regeneration - physiology
Rac
Rho and Ras GTPase
Semaphorin
Signal Transduction - physiology
Spinal Cord Injuries - physiopathology
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Summary:The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute to regeneration failure. In this review, we focus on intrinsic factors that impact regeneration, in particular integrin receptors and their downstream signaling pathways. We discuss studies that address the impact of integrins and integrin signaling pathways on growth cone guidance and motility and how lessons learned from these studies apply to spinal cord regeneration in vivo.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2007.05.027