Involvement of the SgIGSF/Necl-2 adhesion molecule in degranulation of mesenteric mast cells

Abstract Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture. In the steady-state mesentery of mice, the proportion of morphologically degranulating mast cells was approximately 20%, and it increased nearly two-fold when t...

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Bibliographic Details
Published in:Journal of neuroimmunology 2007-03, Vol.184 (1), p.209-213
Main Authors: Ito, Akihiko, Hagiyama, Man, Oonuma, Junko, Murakami, Yoshinori, Yokozaki, Hiroshi, Takaki, Miyako
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Bone Marrow Transplantation - methods
Capsaicin - pharmacology
Cell Adhesion Molecule-1
Cell Adhesion Molecules
Cell Degranulation - drug effects
Cell Degranulation - physiology
Cell Degranulation - radiation effects
Electric Stimulation - methods
IGSF4
Immunoglobulins - deficiency
Immunoglobulins - physiology
Mast cell
Mast Cells - drug effects
Mast Cells - physiology
Membrane Proteins - deficiency
Membrane Proteins - physiology
Mesentery - cytology
Mesentery - surgery
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Microphthalmia-Associated Transcription Factor - genetics
MITF
Neurology
Peripheral Nerves - physiology
Substance P
Tumor Suppressor Proteins - deficiency
Tumor Suppressor Proteins - physiology
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Summary:Abstract Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture. In the steady-state mesentery of mice, the proportion of morphologically degranulating mast cells was approximately 20%, and it increased nearly two-fold when the mesenteric nerve root was stimulated electrically. In contrast, there was no significant increase detectable in the mesentery of MITF-mutants, from which bone marrow-derived cultured mast cells (BMMCs) lack SgIGSF. BMMCs from SgIGSF-knockout mice transplanted to the mesentery of mast cell-deficient W/Wv mice did not degranulate in response to the mesenteric nerve stimulation, whereas transfection with SgIGSF cDNA restored those responses. SgIGSF appeared to promote communication between nerves and mast cells in the murine mesentery.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2006.12.008