Vascular stiffness in familial hypercholesterolaemia is associated with C-reactive protein and cholesterol burden

• Published in: European journal of clinical investigation 2007-03, Vol.37 (3), p.197-206
• Main Authors: Cheng, H. M., Ye, Z. X., Chiou, K. R., Lin, S. J., Charng, M. J.
• Format: Article
• Language: English
• Subjects: Adult; Arterial stiffness; atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - physiopathology; Biological and medical sciences; C-Reactive Protein - physiology; Case-Control Studies; Disorders of blood lipids. Hyperlipoproteinemia; Elasticity; familial hypercholesterolaemia; Female; General aspects; Humans; Hypercholesterolemia - genetics; Hypercholesterolemia - physiopathology; intima-medial thickness; Male; Medical sciences; Metabolic diseases; Pedigree; pulse wave velocity; Risk Factors; Tunica Intima - physiopathology; Vascular Resistance - physiology
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/j.1365-2362.2007.01772.x

Background  Familial hypercholesterolaemia (FH) is characterized by very high serum cholesterol and premature coronary atherosclerosis. Arterial stiffness and atherosclerosis are two major underlying pathophysiologies of arterial disease that are predictive of future cardiovascular events. The aims of this study were to quantify atherosclerosis and arterial stiffness and to evaluate their relationship with high sensitive C‐reactive protein (hs‐CRP) and the level of exposure to high serum cholesterol in FH patients. Materials and methods  We measured traditional risk factors, hs‐CRP, intima‐media thickness (IMT) of carotid artery, and brachial‐ankle pulse wave velocity (baPWV) in 35 heterozygous FH subjects and 17 healthy control subjects. Cholesterol‐year score (CYS) was calculated to estimate the lifetime cholesterol burden in FH subjects. Results  FH subjects had significantly elevated total cholesterol, low‐density lipoprotein cholesterol, and carotid IMT compared with those without mutations. Among FH patients, the baPWV and carotid IMT were higher in cases with high cholesterol burden than those without. Similarly, the baPWV and carotid IMT were also higher in cases with elevated hs‐CRP (> 1 mg L−1) than those without. Multiple linear regression analysis demonstrated CYS and hs‐CRP were significant independent predictors of baPWV and IMT in FH patients. Conclusions  Both high cholesterol burden and vascular inflammation are not only associated with atherosclerosis, but also contribute to the development of arterial stiffness in FH patients. Early detection of hypercholesterolaemia in FH patients is warranted to prevent the untoward pathophysiologies.