Methods for behavioral testing of spinal cord injured rats

Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for evaluating the extent of injury and treatment efficacy. For this purpose, a number of behavioral testing methods can be used. In this review, 35 individual locomotor, motor, sensory, sensory–motor, autonomic or...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2008, Vol.32 (3), p.550-580
Main Authors: SEDY, Jiri, URDZIOKOVA, Lucia, JENDELOVA, Pavla, SYKOVA, Eva
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Behavioral Research - methods
Behavioral testing
Biological and medical sciences
Cerebrospinal fluid. Meninges. Spinal cord
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Medical sciences
Method
Motor Skills
Nerve Regeneration - physiology
Nervous system (semeiology, syndromes)
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Recovery of Function - physiology
Spinal Cord Injuries
Spinal cord injury
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Summary:Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for evaluating the extent of injury and treatment efficacy. For this purpose, a number of behavioral testing methods can be used. In this review, 35 individual locomotor, motor, sensory, sensory–motor, autonomic or electrophysiological behavioral tests, their weaknesses and strengths, testing conditions, the need for habituation, pre-training and/or food deprivation, methods for increasing the animals’ skills, systematic testing protocols and methods for selecting the proper behavioral tests for particular injury models are discussed on the basis of a retrospective analysis of scientific studies published from 1995 to 2007. This review is primarily targeted towards researchers outside the field or to researchers new to the field of SCI.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2007.10.001