Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones

This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sod...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2008-01, Vol.63 (1), p.3-11
Main Authors: Groban, Leanne, Yamaleyeva, Liliya M., Westwood, Brian M., Houle, Timothy T., Lin, Marina, Kitzman, Dalane W., Chappell, Mark C.
Format: Article
Language:English
Subjects:
Age
Aldosterone - blood
Animals
Blood Pressure - drug effects
Cardiovascular disease
Diastole - drug effects
Estrogens - deficiency
Estrogens - physiology
Female
Heart failure
Heart Failure, Diastolic - physiopathology
Laboratory animals
Menopause
Mice
ovarian—Diastolic function—Rat
Ovariectomy
Rats
Rats, Inbred Lew
Renin
Risk factors
Salt—Hormone
Sodium Chloride, Dietary - pharmacology
Tissues
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - physiopathology
Womens health
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Summary:This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sodium chloride) diet exhibited early diastolic dysfunction when compared to normal salt-fed (NS) (1% sodium chloride) rats. In contrast, ovariectomized (OVX) rats on either NS or HS diets showed impaired relaxation with evidence of elevated left ventricular filling pressures (E/e′) or pseudonormalization. This more advanced stage of diastolic dysfunction was associated with increases in interstitial cardiac fibrosis and high circulating levels of aldosterone, two factors leading to reduced ventricular compliance. These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/63.1.3