Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double‐blinded “on” versus “off” manner demonstrated that stimulati...

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Bibliographic Details
Published in:Annals of neurology 2008-01, Vol.63 (1), p.119-123
Main Authors: Hamani, Clement, McAndrews, Mary Pat, Cohn, Melanie, Oh, Michael, Zumsteg, Dominik, Shapiro, Colin M., Wennberg, Richard A., Lozano, Andres M.
Format: Article
Language:English
Subjects:
Appetite - physiology
Appetite Regulation - physiology
Biological and medical sciences
Deep Brain Stimulation - methods
Denervation - methods
Drug toxicity and drugs side effects treatment
Fornix, Brain - anatomy & histology
Fornix, Brain - physiology
Hippocampus - anatomy & histology
Hippocampus - physiology
Humans
Hypothalamus - anatomy & histology
Hypothalamus - physiology
Male
Medical sciences
Memory - physiology
Memory Disorders - therapy
Middle Aged
Neural Pathways - anatomy & histology
Neural Pathways - physiology
Neurology
Obesity, Morbid - therapy
Parahippocampal Gyrus - anatomy & histology
Parahippocampal Gyrus - physiology
Pharmacology. Drug treatments
Toxicity: nervous system and muscle
Treatment Outcome
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Summary:Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double‐blinded “on” versus “off” manner demonstrated that stimulation increased recollection but not familiarity‐based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions. Ann Neurol 2008;63:119–123
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.21295