Human Variability of fMRI Brain Activation in Response to Oculomotor Stimuli

Assessing interindividual variability of brain activation is of practical importance to the use of functional magnetic resonance imaging (fMRI) in the clinical context. The main objective of this study is to analyze the variability of the oculomotor system through horizontal optokinetic, pursuit and...

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Bibliographic Details
Published in:Brain topography 2008-03, Vol.20 (3), p.113-121
Main Authors: Della-Justina, Hellen M., Pastorello, Bruno F., Santos-Pontelli, Taiza E. G., Pontes-Neto, Octavio M., Santos, Antonio Carlos, Baffa, Oswaldo, Colafemina, Jose F., Leite, Joao P., de Araujo, Draulio B.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Brain Mapping
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Evoked Potentials, Visual - physiology
Female
Frontal Lobe - anatomy & histology
Frontal Lobe - physiology
Humans
Magnetic Resonance Imaging
Male
Neurology
Neurosciences
Nystagmus, Optokinetic - physiology
Original Paper
Photic Stimulation
Psychiatry
Saccades - physiology
Temporal Lobe - anatomy & histology
Temporal Lobe - physiology
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Summary:Assessing interindividual variability of brain activation is of practical importance to the use of functional magnetic resonance imaging (fMRI) in the clinical context. The main objective of this study is to analyze the variability of the oculomotor system through horizontal optokinetic, pursuit and saccadic eye movement stimulations by means of fMRI. We found significant activation of many cortical and subcortical structures. The frequency of activation demonstrates a high variability between subjects. However, the most frequent activation regions were located in frontal areas and in regions comprising the middle temporal and medial superior temporal areas. Our study allowed the characterization of the most frequently involved foci in optokinetic stimulation, pursuit and saccadic eye movement tasks. The combination of these tasks constitutes a suitable tool for mapping major areas involved in the oculomotor system.
ISSN:0896-0267
1573-6792
DOI:10.1007/s10548-007-0037-y