Homocysteine is a potent modulator of plasma membrane electron transport systems

The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that hom...

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Bibliographic Details
Published in:Journal of bioenergetics and biomembranes 2008-02, Vol.40 (1), p.45-51
Main Authors: Rodríguez-Alonso, Javier, Montañez, Raúl, Rodríguez-Caso, Luis, Medina, Miguel Ángel
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Animals
Antineoplastic Agents - pharmacology
Biochemistry
Bioenergetics
Bioorganic Chemistry
Cancer
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cattle
Cell Line, Tumor
Cell Membrane - metabolism
Cell Membrane - pathology
Chemistry
Chemistry and Materials Science
Deregulation
Electron Transport - drug effects
Electrons
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Enzymes
Health risks
Histology
Homocysteine
Homocysteine - pharmacology
Humans
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - metabolism
Hyperhomocysteinemia - pathology
Membranes
Morphology
NADPH Oxidases - metabolism
Neoplasm Proteins - metabolism
Neoplasms - drug therapy
Neoplasms - enzymology
Organic Chemistry
Oxidation-Reduction - drug effects
Oxidizing agents
Plasma
Risk Factors
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Summary:The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that homocysteine, as a redox active compound, could modulate the endothelial plasma membrane redox system. We show that homocysteine behaves as a very potent stimulator of this activity. Furthermore, we show that this inducing effect is also produced on tumor cells and that it can be observed at both the activity and protein levels. On the other hand, homocysteine treatment decreases the activity of the specific ectocellular tumor NADH oxidase. Taken together, these results underscore a potential antitumoral action of homocysteine.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-008-9127-0