Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail

• Published in: Neuroscience letters 2007-03, Vol.415 (2), p.102-107
• Main Authors: Shousha, Saad, Nakahara, Keiko, Nasu, Tetsuo, Sakamoto, Takumi, Murakami, Noboru
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Body temperature; Body Temperature - drug effects; Coturnix - physiology; Dose-Response Relationship, Drug; Eating - drug effects; Food intake; Fundamental and applied biological sciences. Psychology; Glucagon-like peptide; Glucagon-Like Peptide 1 - pharmacology; Glucagon-Like Peptide 2 - pharmacology; Japanese quail; Male; Motor Activity - drug effects; Time Factors; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2007.01.007

To investigate the physiological roles of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in avian species, we elucidated the effect of intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of GLP-1 and GLP-2 on food intake, body temperature and gross locomotor activity in adult Japanese quail. Both i.p. and i.c.v. administration of GLP-1 suppressed food intake at 2, 4 and 12 h after administration. Moreover, both i.p. and i.c.v. administration of GLP-1 significantly decreased both body temperature and gross locomotor activity 2 h after administration. On the other hand, both i.p. and i.c.v. administration of GLP-2 had no effect on food intake, body temperature or gross locomotor activity. These results suggest that GLP-1 may have an important role in the regulation of food intake, body temperature and locomotor activity while GLP-2 may have no apparent effect on feeding regulation in adult Japanese quail.