Double-quantum filtered heteronuclear correlation spectroscopy under magic angle spinning

We present a simple experimental method to extract the van Vleck second moment of a multiple-spin system under high-resolution condition. The idea is to incorporate a double-quantum (DQ) filter into the pulse sequence of heteronuclear correlation spectroscopy so that a DQ excitation profile can be o...

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Bibliographic Details
Published in:Solid state nuclear magnetic resonance 2007-02, Vol.31 (1), p.55-61
Main Authors: Tseng, Yao-Hung, Tsai, Yi-Ling, . Tsai, Tim W.T, Lin, Chun-Pin, Huang, Shih-Hao, Mou, Chung-Yuan, Chan, Jerry C.C.
Format: Article
Language:English
Subjects:
Animals
Brushite
Calcium phosphate
Computer Simulation
Dentin
Dentin - chemistry
Double-quantum filter
Durapatite - chemistry
HAp
HETCOR
In Vitro Techniques
Incisor - chemistry
Models, Biological
Models, Chemical
NMR
Nuclear Magnetic Resonance, Biomolecular - methods
Rats
Rats, Wistar
Reproducibility of Results
Second moment
Sensitivity and Specificity
Spin Labels
Teeth
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Summary:We present a simple experimental method to extract the van Vleck second moment of a multiple-spin system under high-resolution condition. The idea is to incorporate a double-quantum (DQ) filter into the pulse sequence of heteronuclear correlation spectroscopy so that a DQ excitation profile can be obtained by measuring a series of 2D spectra. The effects of spinning frequency and proton decoupling are demonstrated on the measurements of two model compounds, viz. hydroxyapatite and brushite. Based on the results obtained for the model compounds, the P-31 homonuclear second moment of the apatite component in rat dentin is characterized. The method is generally suited for the study of bone, enamel and dentin.
ISSN:0926-2040
1527-3326
DOI:10.1016/j.ssnmr.2007.01.001