A novel murine model of pharyngeal candidiasis with local symptoms characteristic of pharyngeal thrush produced by using an inhaled corticosteroid

We established a novel murine model of pharyngeal candidiasis maintaining stable yeast population and local symptoms characteristic of pharyngeal thrush. The persistent Candida-infection was prolonged by inhalation of beclomethasone dipropionate corticosteroid. The severity of infection lesions was...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2007-03, Vol.45 (2), p.143-148
Main Authors: Hu, Weimin, Ninomiya, Kentaro, Ishibashi, Hiroko, Maruyama, Naho, Oshima, Haruyuki, Yamaguchi, Hideyo, Abe, Shigeru
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Antifungal Agents - therapeutic use
Beclomethasone - administration & dosage
Candida albicans - growth & development
Candidiasis, Oral - drug therapy
Candidiasis, Oral - microbiology
Colony Count, Microbial
Disease Models, Animal
Female
Fluconazole - therapeutic use
Histocytochemistry
Immunosuppressive Agents - administration & dosage
Mice
Mice, Inbred ICR
Pharynx - microbiology
Pharynx - pathology
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Summary:We established a novel murine model of pharyngeal candidiasis maintaining stable yeast population and local symptoms characteristic of pharyngeal thrush. The persistent Candida-infection was prolonged by inhalation of beclomethasone dipropionate corticosteroid. The severity of infection lesions was evaluated by determining viable cell number of Candia albicans and scores representing symptomatic curd-like white patch on pharyngeal tissue. The utility of this model was shown by the disappearance of lesions and fungal cells after treatment with fluconazole (FLCZ). The model would be useful for evaluating new chemotherapeutic or immunotherapeutic approaches against pharyngeal candidiasis, as well as in pathological studies.
ISSN:1369-3786
1460-2709
DOI:10.1080/13693780601103098