Neuronal Plasticity and Functional Recovery After Ischemic Stroke

Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical altern...

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Bibliographic Details
Published in:Topics in stroke rehabilitation 2008-01, Vol.15 (1), p.42-50
Main Authors: Cheatwood, Joseph L., Emerick, April J., Kartje, Gwendolyn L.
Format: Article
Language:English
Subjects:
Aged
amphetamine
Animals
Brain Ischemia - complications
hemispatial neglect
Humans
Immunotherapy
Motion Therapy, Continuous Passive
movement-based therapies
Myelin Proteins - immunology
myelin-associated outgrowth inhibitors
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Nogo Proteins
Nogo-A
physical therapy
Rats
Recovery of Function - physiology
rodents
skilled reaching
Stem Cell Transplantation
Stroke - etiology
Stroke - physiopathology
Stroke - psychology
Stroke - therapy
Stroke Rehabilitation
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Summary:Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical alternatives to improve functional recovery after stroke is actively under investigation. Anti-Nogo-A immunotherapy to reduce the central nervous system inhibitory environment, cell transplantation strategies, pharmacological agents, and movement-based therapies represent emerging treatments of poststroke deficits through enhancement of neuroanatomical plasticity.
ISSN:1074-9357
1945-5119
DOI:10.1310/tsr1501-42