Role of metalloproteinases in platelet function

Abstract Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating...

Full description

Saved in:
Bibliographic Details
Published in:Thrombosis research 2008-01, Vol.121 (4), p.535-542
Main Authors: Santos-Martínez, María José, Medina, Carlos, Jurasz, Paul, Radomski, Marek W
Format: Article
Language:English
Subjects:
ADAM Proteins - physiology
ADAM17 Protein
ADAMs
ADAMTS
ADAMTS13 Protein
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood coagulation. Blood cells
Blood Platelets - physiology
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Fundamental and applied biological sciences. Psychology
Hematology, Oncology and Palliative Medicine
Humans
Inflammation - etiology
Matrix metalloproteinases
Medical sciences
Metalloproteases - physiology
Molecular and cellular biology
Platelet
Platelet Aggregation
Platelets
TIMPs
Vascular Diseases - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2007.06.002