Mammalian collagen receptors

Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of tissues, but are also intimately involved in controlling cell behaviour. The hallmark of collagens is a triple helix made up of polypeptide chains...

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Bibliographic Details
Published in:Matrix biology 2007-04, Vol.26 (3), p.146-155
Main Authors: Leitinger, Birgit, Hohenester, Erhard
Format: Article
Language:English
Subjects:
Animals
Cell adhesion
Collagen
Collagen - chemistry
Collagen - genetics
Collagen - metabolism
Discoidin Domain Receptors
Hemostasis
Integrin
Integrins - chemistry
Integrins - genetics
Integrins - metabolism
Lectins, C-Type - chemistry
Lectins, C-Type - genetics
Lectins, C-Type - metabolism
Mannose-Binding Lectins - chemistry
Mannose-Binding Lectins - genetics
Mannose-Binding Lectins - metabolism
Models, Molecular
Platelet Membrane Glycoproteins - chemistry
Platelet Membrane Glycoproteins - genetics
Platelet Membrane Glycoproteins - metabolism
Protein Conformation
Receptor Protein-Tyrosine Kinases - chemistry
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Receptor tyrosine kinase
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Receptors, Collagen - chemistry
Receptors, Collagen - genetics
Receptors, Collagen - metabolism
Receptors, Immunologic - chemistry
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Receptors, Mitogen - chemistry
Receptors, Mitogen - genetics
Receptors, Mitogen - metabolism
Triple helix
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Summary:Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of tissues, but are also intimately involved in controlling cell behaviour. The hallmark of collagens is a triple helix made up of polypeptide chains containing glycine-X-Y repeats. A structurally and functionally diverse group of cell surface receptors mediates the recognition of triple-helical collagen: integrins, discoidin domain receptors, glycoprotein VI, leukocyte-associated IG-like receptor-1, and members of the mannose receptor family. In this review, we discuss the structure and function of these receptors, focussing on the principles involved in collagen recognition.
ISSN:0945-053X
1569-1802
DOI:10.1016/j.matbio.2006.10.007