Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease

Abstract Background We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. Methods Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant corona...

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Bibliographic Details
Published in:Atherosclerosis 2007-04, Vol.191 (2), p.348-354
Main Authors: Sharma, Rajan, Pellerin, Denis, Gaze, David C, Mehta, Rajnikant L, Gregson, Helen, Streather, Christopher P, Collinson, Paul O, Brecker, Stephen J.D
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcinosis - complications
Calcinosis - etiology
Calcinosis - mortality
Calcinosis - pathology
Cardiac calcification
Cardiology. Vascular system
Cardiovascular
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - etiology
Coronary Artery Disease - mortality
Coronary Artery Disease - pathology
Coronary heart disease
Echocardiography
End stage renal disease
Female
Follow-Up Studies
Heart
Heart Valve Diseases - complications
Heart Valve Diseases - etiology
Heart Valve Diseases - mortality
Heart Valve Diseases - pathology
Heart Ventricles - pathology
Humans
Kaplan-Meier Estimate
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - pathology
Kidney Failure, Chronic - physiopathology
Male
Medical sciences
Middle Aged
Mitral annular calcification
Mitral Valve - pathology
Mortality
Predictive Value of Tests
Prospective Studies
Renal transplant candidates
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Time Factors
United Kingdom - epidemiology
Ventricular Function, Left
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Summary:Abstract Background We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. Methods Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was defined as luminal stenosis >70% by visual estimation in at least one coronary artery. Results There were 21 deaths over a follow-up period of 2.2 ± 0.7 years. MAC occurred in 56 patients (40%) and was associated with higher mortality ( p = 0.04). Patients with MAC were older ( p =
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2006.03.033