Glutathione S-transferase polymorphisms and oral cancer: A case-control study in Rio de Janeiro, Brazil

Summary This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro. DNA extracted from white blood cells of 231 oral cancer patients and 212 hospital controls was analyzed by polymerase chain reac...

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Bibliographic Details
Published in:Oral oncology 2008-02, Vol.44 (2), p.200-207
Main Authors: Hatagima, Ana, Costa, Emmerson C.B, Marques, Christiane F.S, Koifman, Rosalina J, Boffetta, Paolo, Koifman, Sergio
Format: Article
Language:English
Subjects:
Adult
Aged
Brazil
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - genetics
Case-Control Studies
Female
Gene Frequency
Genetic polymorphism
Genetic Predisposition to Disease
Genotype
Glutathione Transferase - genetics
GSTM1
GSTP1
GSTT1
Hematology, Oncology and Palliative Medicine
Humans
Isoenzymes - genetics
Likelihood Functions
Male
Middle Aged
Molecular Epidemiology
Mouth Neoplasms - enzymology
Mouth Neoplasms - genetics
Oral cancer
Otolaryngology
Polymorphism, Genetic
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Summary:Summary This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro. DNA extracted from white blood cells of 231 oral cancer patients and 212 hospital controls was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. GSTM1 polymorphism distribution was different between cases and controls ( P = 0.006), with an overrepresentation of GSTM1 A/B genotype in controls. GSTM1 A/B individuals were at decreased oral cancer risk (OR = 0.08; 95% CI = 0.05–0.62). No statistically significant association was observed for GSTT1 and GSTP1 polymorphisms. Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer. Therefore, these results do not support the hypothesis of increased risk of GSTP1 G/G, GSTM1 or GSTT1 null genotypes for developing cancer in oral cavity, but the GSTM1 A/B genotype emerged as a protective factor.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2007.02.001