A Common 8q24 Variant and the Risk of Colon Cancer: A Population-Based Case-Control Study

Three recent studies identified common variants on 8q24 that confer modestly increased susceptibility to colorectal cancer. Here, we replicate the association in a population-based case-control study of colon cancer, including 561 cases and 721 unrelated controls. The rs6983267 marker was significan...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-02, Vol.17 (2), p.339-342
Main Authors: LI LI, PLUMMER, Sarah J, THOMPSON, Cheryl L, MERKULOVA, Alona, ACHESON, Louise S, TUCKER, Thomas C, CASEY, Graham
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Case-Control Studies
Chromosomes, Human, Pair 8 - genetics
Colon cancer
Colonic Neoplasms - epidemiology
Colonic Neoplasms - genetics
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal cancers: colorectal
Genetic Predisposition to Disease
Genotype
Genotype-phenotype correlations
Humans
Incidence
Kentucky - epidemiology
Logistic Models
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
SEER Program
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Three recent studies identified common variants on 8q24 that confer modestly increased susceptibility to colorectal cancer. Here, we replicate the association in a population-based case-control study of colon cancer, including 561 cases and 721 unrelated controls. The rs6983267 marker was significantly associated with colon cancer risk. Compared with those homozygous for the T allele, the heterozygous and homozygous carriers for the G allele had an age-adjusted odds ratio of 1.39 (95% confidence interval, 1.03-1.88) and 1.68 (95% confidence interval, 1.21-2.33), respectively. An additive model showed strong evidence for a gene-dose response relationship ( P trend = 0.0022). The association remained statistically significant when restricted to Caucasians only (527 cases and 679 controls; P trend = 0.0056). Further adjustment for other known risk factors did not alter the results. Stratified analysis revealed no evidence for effect modification by family history of colorectal cancer, age, or gender. These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(2):339–42)
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-07-0713