Symptomatic Peripheral Arterial Disease in Women : Nontraditional Biomarkers of Elevated Risk

Most investigations of novel biomarkers for prediction of cardiovascular disease pertain to coronary artery disease. Few large-scale prospective studies have critically assessed plasma-based factors as predictors of peripheral arterial disease (PAD), and comparative data between individual biomarker...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2008-02, Vol.117 (6), p.823-831
Main Authors: PRADHAN, Aruna D, SHRIVASTAVA, Sanjay, COOK, Nancy R, RIFAI, Nader, CREAGER, Mark A, RIDKER, Paul M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
C-Reactive Protein - analysis
Cardiology. Vascular system
Cholesterol, HDL - blood
Coronary heart disease
Creatinine - metabolism
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Fibrinogen - analysis
Heart
Humans
Intercellular Adhesion Molecule-1 - blood
Lipoprotein(a) - blood
Medical sciences
Middle Aged
Multivariate Analysis
Peripheral Vascular Diseases - blood
Prospective Studies
Risk Assessment - methods
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Summary:Most investigations of novel biomarkers for prediction of cardiovascular disease pertain to coronary artery disease. Few large-scale prospective studies have critically assessed plasma-based factors as predictors of peripheral arterial disease (PAD), and comparative data between individual biomarkers and lipid levels are sparse, especially among women. We evaluated the relationship between baseline levels of several novel biomarkers and confirmed incident symptomatic PAD (n=100) in a prospective cohort study (median follow-up, 12.3 years) involving 27,935 US female health professionals > or = 45 years of age without diagnosed vascular disease at baseline. Biomarkers assessed were high-sensitivity C-reactive protein, fibrinogen, soluble intercellular adhesion molecule-1 (sICAM-1), homocysteine, lipoprotein(a), hemoglobin A1c, creatinine, and conventional lipid levels. In univariate analyses, levels of high-sensitivity C-reactive protein, fibrinogen, sICAM-1, homocysteine, lipoprotein(a), creatinine clearance, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and the ratio of total cholesterol to HDL-C (TC:HDL-C) were significantly related to PAD (all P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.107.719369