Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus

Objective. Resistin has been linked to obesity, type 2 diabetes, inflammation and atherosclerosis but the results of animal and human studies have been at variance. The purpose of this study was to investigate the potential roles of resistin in patients with type 2 diabetes and to evaluate the corre...

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Published in:Scandinavian journal of clinical and laboratory investigation 2007, Vol.67 (2), p.215-225
Main Authors: Mojiminiyi, O. A., Abdella, N. A.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Body Mass Index
Comorbidity
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Inflammation
Inflammation - blood
Inflammation - complications
Inflammation - epidemiology
insulin resistance
Kuwait - epidemiology
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Middle Aged
Odds Ratio
resistin
Resistin - blood
type 2 diabetes mellitus
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Summary:Objective. Resistin has been linked to obesity, type 2 diabetes, inflammation and atherosclerosis but the results of animal and human studies have been at variance. The purpose of this study was to investigate the potential roles of resistin in patients with type 2 diabetes and to evaluate the correlation between resistin and markers of obesity, inflammation, insulin resistance, metabolic parameters, diabetes control and complications. Material and methods. Fasting resistin, leptin, insulin, glucose, HbA1c, full lipid profile, C-reactive protein (CRP) (high sensitivity assay) and complete blood count were determined in 135 patients with type 2 diabetes. Univariate regression and multivariate logistic regression analyses were used to relate resistin with indices of obesity, inflammation, insulin resistance (homeostasis model, HOMA), insulin sensitivity, diabetic control, coronary heart disease (CHD) and degree of microalbuminuria. Results. Resistin showed significant (p
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510601032532