Cardiac functions in children with coeliac disease during follow-up: Insights from tissue Doppler imaging

Abstract Background The identification of a coeliac disease in patients with idiopathic dilated cardiomyopathy raises critical questions on the relationship between the two entities. But cardiac functions have not been studied in patients with coeliac disease. The present study was undertaken to ass...

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Bibliographic Details
Published in:Digestive and liver disease 2008-03, Vol.40 (3), p.182-187
Main Authors: Polat, Tugcin B, Urganci, Nafiye, Yalcin, Yalim, Zeybek, Cenap, Akdeniz, Celal, Erdem, Abdullah, Imanov, Elnur, Celebi, Ahmet
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Anti-Idiotypic - blood
Atrial Function - physiology
Cardiac function
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - etiology
Cardiomyopathy, Dilated - physiopathology
Celiac Disease - complications
Celiac Disease - immunology
Celiac Disease - physiopathology
Child
Child, Preschool
Children
Coeliac disease
Echocardiography, Doppler - methods
EMA
Female
Follow-Up Studies
Gastroenterology and Hepatology
Heart Atria - diagnostic imaging
Heart Atria - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Immunoglobulin A - immunology
Male
Myocardial Contraction - physiology
Prognosis
Serology
Time Factors
Tissue Doppler echocardiography
Ventricular Function - physiology
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Summary:Abstract Background The identification of a coeliac disease in patients with idiopathic dilated cardiomyopathy raises critical questions on the relationship between the two entities. But cardiac functions have not been studied in patients with coeliac disease. The present study was undertaken to assess cardiac functions by Tissue Doppler Echocardiography in patient with coeliac disease. Methods We studied 45 clinically stable patients; twenty-five patients with positive serum IgA Antiendomysial Antibody levels (Group 1), twenty patients with negative serum IgA Antiendomysial Antibody levels (Group 2) at the time of echocardiographic study. Control group consisted of 30 healthy children free of any disease. Results Myocardial systolic wave velocity of the mitral annulus was significantly lower ( p < 0.001), myocardial precontraction and contraction time were slightly longer in Group 2 when compared control group ( p = 0.015, p = 0.044, respectively). There was a negative correlation between the serum IgA Antiendomysial Antibody levels titers and myocardial systolic wave levels of all patients included in the study ( r = −0.633; p < 0.001). A myocardial systolic wave velocity of
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2007.11.014