Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats

The objectives of this study were to investigate and compare the monocyte chemoattractant protein-1 (MCP-1) levels of gingival tissues in diabetes mellitus (DM) and periodontitis and to reveal the effects of MCP-1 on periodontal inflammation and destruction in these diseases. DM was created in 15 ra...

Full description

Saved in:
Bibliographic Details
Published in:Clinical oral investigations 2008-03, Vol.12 (1), p.83-89
Main Authors: Sakallıoğlu, Elif Eser, Ayas, Bülent, Lütfioğlu, Müge, Keleş, Gonca Çayir, Açıkgöz, Gökhan, Fıratlı, Erhan
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - classification
Alveolar Bone Loss - immunology
Animals
Autoantigens - analysis
Chemokine CCL2 - analysis
Connective Tissue - pathology
Cytokines - analysis
Dentistry
Diabetes Mellitus, Experimental - immunology
Epithelium - pathology
Gingiva - immunology
Gingiva - pathology
Gingivitis - immunology
Gingivitis - pathology
Lymphocytes - pathology
Male
Medicine
Monocytes - pathology
Original Article
Periodontitis - immunology
Periodontitis - pathology
Rats
Rats, Sprague-Dawley
Streptozocin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objectives of this study were to investigate and compare the monocyte chemoattractant protein-1 (MCP-1) levels of gingival tissues in diabetes mellitus (DM) and periodontitis and to reveal the effects of MCP-1 on periodontal inflammation and destruction in these diseases. DM was created in 15 rats (group 1) by streptozotocin injection, and periodontitis was obtained by ligature induction in 15 rats (group 2). Fifteen systemically and periodontally healthy rats were used as control (group 3). Gingival MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Periodontal inflammation was quantified by the inflammatory cell infiltration in the gingival samples, whereas periodontal destruction was assessed by the alveolar bone loss in the experimental regions. MCP-1 concentrations were higher in groups 1 and 2 than in group 3 ( p  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-007-0148-6