Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans

• Published in: Journal of applied physiology (1985) 2008-02, Vol.104 (2), p.475-481
• Main Authors: Soller, Babs R, Yang, Ye, Soyemi, Olusola O, Ryan, Kathy L, Rickards, Caroline A, Walz, J. Matthias, Heard, Stephen O, Convertino, Victor A
• Format: Article
• Language: English
• Subjects: Adipose Tissue - metabolism; Adult; Biological and medical sciences; Blood Pressure; Blood Volume; Cardiology; Electrocardiography; Female; Fundamental and applied biological sciences. Psychology; Heart Rate; Hemodynamics; Humans; Hydrogen-Ion Concentration; Hypovolemia - diagnosis; Hypovolemia - metabolism; Hypovolemia - physiopathology; Lower Body Negative Pressure; Male; Models, Cardiovascular; Muscle, Skeletal - metabolism; Muscular system; Oxygen; Oxygen - blood; Oxygen - metabolism; Oxygen Consumption; Skin - metabolism; Spectrophotometry, Infrared; Spectrum analysis; Stroke Volume; Time Factors; Vascular Resistance
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00600.2007

1 Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts; and 2 U. S. Army Institute of Surgical Research, Fort Sam Houston, Texas Submitted 5 June 2007 ; accepted in final form 13 November 2007 Ten healthy human volunteers were subjected to progressive lower body negative pressure (LBNP) to the onset of cardiovascular collapse to compare the response of noninvasively determined skin and fat corrected deep muscle oxygen saturation (SmO 2 ) and pH to standard hemodynamic parameters for early detection of imminent hemodynamic instability. Muscle SmO 2 and pH were determined with a novel near infrared spectroscopic (NIRS) technique. Heart rate (HR) was measured continuously via ECG, and arterial blood pressure (BP) and stroke volume (SV) were obtained noninvasively via Finometer and impedance cardiography on a beat-to-beat basis. SmO 2 and SV were significantly decreased during the first LBNP level (–15 mmHg), whereas HR and BP were late indicators of impending cardiovascular collapse. SmO 2 declined in parallel with SV and inversely with total peripheral resistance, suggesting, in this model, that SmO 2 is an early indicator of a reduction in oxygen delivery through vasoconstriction. Muscle pH decreased later, suggesting an imbalance between delivery and demand. Spectroscopic determination of SmO 2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume. tissue oxygen; near infrared spectroscopy; physiological monitoring; hemodynamic instability; lower body negative pressure Address for reprint requests and other correspondence: B. R. Soller, Dept. of Anesthesiology, UMass Medical School, 55 Lake Ave North, Worcester, MA 01655 (e-mail: babs.soller{at}umassmed.edu )