Examination of depth-weighted optical signals during cardiac optical mapping: A simulation study

Abstract Optical mapping has become a powerful tool to explore complex cardiac propagation. Many experiments and studies claimed that the fluorescence obtained from tissue surface is the averaged response of the transmembrane potential upon probing depth rather than only on the surface. With the ele...

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Bibliographic Details
Published in:Computers in biology and medicine 2007-05, Vol.37 (5), p.732-738
Main Authors: Xu, Zhenghong, Zhang, Zhenxi, Jin, Yinbin, Wang, Jing
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Algorithms
Body Surface Potential Mapping - methods
Cardiac electrophysiology
Coloring Agents
Computer Simulation
Electrocardiography
Electrochemistry
Energy Transfer
Fluorescence
Heart - physiology
Heart Conduction System - physiology
Humans
Internal Medicine
Life sciences
Light
Membrane Potentials - physiology
Models, Cardiovascular
Monte Carlo simulation
Optical mapping
Optics
Other
Photons
Propagation
Science
Signal processing
Spectrum analysis
Studies
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Summary:Abstract Optical mapping has become a powerful tool to explore complex cardiac propagation. Many experiments and studies claimed that the fluorescence obtained from tissue surface is the averaged response of the transmembrane potential upon probing depth rather than only on the surface. With the electrical propagation model and the photon transport model, the effects of depth-weighted optical signals are examined both during a normal excitation wave and a spiral wave. Our results indicate that depth-weighted optical signals may infer cardiac activation dynamics, such as the mode and the direction of the propagation, the spatial distribution of depolarization or repolarization.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2006.07.004