Lactose: A definitive guide to polymorph determination

Lactose is a well-known molecule capable of forming a number of different polymorphs with varied chemical and physical properties. To date, no definitive guide for distinguishing between polymorphs using simple analytical techniques has been available. The information presented in this article aims...

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Bibliographic Details
Published in:International journal of pharmaceutics 2007-04, Vol.334 (1), p.103-114
Main Authors: Kirk, J.H., Dann, S.E., Blatchford, C.G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
CP-MASNMR
Crystallization
Drug Stability
FT-IR
General pharmacology
Lactose
Lactose - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymorphism
Raman
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
X-Ray Diffraction
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Summary:Lactose is a well-known molecule capable of forming a number of different polymorphs with varied chemical and physical properties. To date, no definitive guide for distinguishing between polymorphs using simple analytical techniques has been available. The information presented in this article aims to provide a conclusive guide for identifying the polymorphs of lactose and to successfully unravel years of contradictory research. Data have been collected on single phase polymorphs, prepared from an identical source, adopting the use of in situ and ex situ powder X-ray diffraction, CCD-Raman, FT-IR and 13C– 1H cross-polarisation magic angle spinning NMR (CP-MASNMR) spectroscopy, in order to provide simple methods to discriminate between the polymorphs.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2006.10.026